Putting two and two together: crystal structure of the FGF-receptor complex

Authors
Wiesmann, C de Vos, AM
Citation
C. Wiesmann et Am. De Vos, Putting two and two together: crystal structure of the FGF-receptor complex, STRUCT F D, 7(11), 1999, pp. R251-R255
Citations number
21
Categorie Soggetti
Biochemistry & Biophysics
Journal title
STRUCTURE WITH FOLDING & DESIGN
ISSN journal
09692126 → ACNP
Volume
7
Issue
11
Year of publication
1999
Pages
R251 - R255
Database
ISI
SICI code
0969-2126(19991115)7:11<R251:PTATTC>2.0.ZU;2-4
Abstract
The recently determined crystal structure of an FGF-receptor complex reveal s a surprising architecture and a novel mode of receptor dimerization. The structure also elucidates the role of heparan sulfate proteoglycans in rece ptor activation, showing significant differences from previously proposed m odels.