Ar. Agner et al., Investigation of genotoxic activity of trans-dehydrocrotonin, a clerodane diterpene from Croton cajucara, TER CAR MUT, 19(6), 1999, pp. 377-384
The genotoxic action of three doses of trans-dehydrocrotonin (t-DCTN), an a
ctive ingredient obtained from the bark extracts of an Amazon native plant,
Croton cajucara, were examined in Swiss mouse bone marrow cells in vivo, s
ubmitted to acute intraperitoneal treatment, by micronucleus (MN) and chrom
osomal aberration (CA) tests.
The statistical tests (Anova and Tukey) made to compare the results obtaine
d in each of the three doses of t-DCTN with the negative-control group show
ed that the frequencies of MN and mitotic index were equal to the negative-
control and that the frequencies of CA were lower than that observed in the
negative-control.
Therefore, based on our results it can be said that t-DCTN is not genotoxic
nor cytotoxic to mouse bone marrow cells, submitted to acute intraperitone
al treatment in vivo. (C) 1999 Wiley-Liss, Inc.