Citation
Fx. You et Rj. Twieg, Aromatic nucleophilic substitution with 4-hydroxypyridine, TETRAHEDR L, 40(50), 1999, pp. 8759-8762
Citations number
19
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039
→ ACNP
Volume
40
Issue
50
Year of publication
1999
Pages
8759 - 8762
Database
ISI
SICI code
0040-4039(199912)40:50<8759:ANSW4>2.0.ZU;2-#
Abstract
The compound 4-hydroxypyridine is reacted with aromatic substrates that hav
e a leaving group (usually halogen) and that is activated by an electron-wi
thdrawing group or a heterocycle. Only N-aryl-4(1H)-pyridones are produced
in this efficient aromatic nucleophilic substitution reaction. Some mechani
stic aspects of the reaction have also been examined. (C) 1999 Elsevier Sci
ence Ltd. All rights reserved.