Asymmetric palladium annulation: formal synthesis of (+)-huperzine A

Authors
Chassaing, C Haudrechy, A Langlois, Y
Citation
C. Chassaing et al., Asymmetric palladium annulation: formal synthesis of (+)-huperzine A, TETRAHEDR L, 40(50), 1999, pp. 8805-8809
Citations number
22
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
50
Year of publication
1999
Pages
8805 - 8809
Database
ISI
SICI code
0040-4039(199912)40:50<8805:APAFSO>2.0.ZU;2-Y
Abstract
A new formal stereoselective synthesis of (+)-huperzine A 1 was achieved us ing as a key step a palladium mediated annulation between 2-methylene-1,3-p ropanediol diacetate and (1R,2S)-2-phenylcyclohexanol derived beta-ketoeste r 14. (C) 1999 Elsevier Science Ltd. All rights reserved.