CHARACTERIZATION OF A MUTATION IN THE PARE GENE THAT CONFERS FLUOROQUINOLONE RESISTANCE IN STREPTOCOCCUS-PNEUMONIAE

Authors
PERICHON B TANKOVIC J COURVALIN P
Citation
B. Perichon et al., CHARACTERIZATION OF A MUTATION IN THE PARE GENE THAT CONFERS FLUOROQUINOLONE RESISTANCE IN STREPTOCOCCUS-PNEUMONIAE, Antimicrobial agents and chemotherapy, 41(5), 1997, pp. 1166-1167
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
41
Issue
5
Year of publication
1997
Pages
1166 - 1167
Database
ISI
SICI code
0066-4804(1997)41:5<1166:COAMIT>2.0.ZU;2-8
Abstract
We report a mutation in the parE genes of ho in vitro mutants of Strep tocaccus pneunoniae responsible for low-level resistance to fluoroquin olones. Sequential acquisition of mutations in parE and gyr.4 lends to higher levels of resistance. This confirms that topoisomerase IV is t he primary target of fluoroquinolones in S. pneumoniae.