COMPARATIVE IN-VITRO ACTIVITIES OF DU-6859A, LEVOFLOXACIN, OFLOXACIN,SPARFLOXACIN, AND CIPROFLOXACIN AGAINST 387 AEROBIC AND ANAEROBIC BITE WOUND ISOLATES

The activities of DU-6859a, levofloxacin, ofloxacin, sparfloxacin, and ciprofloxacin against bite wound isolates were determined by the agar dilution method. DU-6859a,vas the most active compound (MICs, less th an or equal to 0.125 mu g/ml) against all Pasteurella species, Staphyl ococcus aureus, and streptococci; anaerobes were susceptible to 10.5 m u g/ml, except fusobacteria, which were susceptible to less than or eq ual to 2 mu g/ml. Against aerobes, levofloxacin was more active than o floxacin (MIG at which 90% of isolates are inhibited [MIC90], less tha n or equal to 1.0 mu g/ml for both) and sparfloxacin and ciprofloxacin were also active (MIC(90)s, less than or equal to 0.25 and less than or equal to 1 mu g/ml, respectively).