ESSENTIAL ROLE OF ENDOGENOUSLY SYNTHESIZED TYLOSIN FOR INDUCTION OF ERMSF IN STREPTOMYCES-FRADIAE

Authors
MEMILI E WEISBLUM B
Citation
E. Memili et B. Weisblum, ESSENTIAL ROLE OF ENDOGENOUSLY SYNTHESIZED TYLOSIN FOR INDUCTION OF ERMSF IN STREPTOMYCES-FRADIAE, Antimicrobial agents and chemotherapy, 41(5), 1997, pp. 1203-1205
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
41
Issue
5
Year of publication
1997
Pages
1203 - 1205
Database
ISI
SICI code
0066-4804(1997)41:5<1203:EROEST>2.0.ZU;2-H
Abstract
We compared ermSF induction in wild-type Streptomyces fradiae NRRL B-2 702 and that in GS-14, a ty1A mutant which cannot synthesize tylosin. Our findings suggest that (i) endogenously synthesized tylosin plays a n obligatory role in ermSF induction and (ii) tylosin, or a biosynthet ic intermediate beyond tylactone, has an ''autocrine'' function that i nduces ErmSF synthesis, thereby enabling S. fradiae to resist higher l evels of tylosin.