This paper reviews some relevant citations regarding the non-specific force
s that must be considered in oral bioadhesive events. These range from forc
es related to restorative dentistry to those related to prevention and mole
cular biology. Types of interactions discussed are: 1. Van der Waal's force
s; 2. electrostatic double-layer forces; 3. solvent-dependent interactions;
4. hydrogen bonding; 5. hydrophobic interactions: 6. hydration forces; 7.
steric forces; and 8. covalent bonds. Examples are given of the various typ
es of interaction that occur at different surface separation (less than or
equal to 400 Angstrom) between adsorbed films of a pure salivary protein fr
action (PRP1).