The influence of the radiation dose on local control and cosmetic outcome i
n breast-conserving treatment for breast cancer is investigated in EORTC tr
ial 22881/10882. In this study 50 Gy is administered to the whole breast, a
nd the effect of an additional dose to the tumor-bearing area (boost dose)
is evaluated. The purpose of this analysis is to document the dose homogene
ity of the radiation dose as reported in the first 1915 treatment forms. re
ceived at the EORTC Data Center. The dose to the prescription Point (A) was
within 95 and 110% of 50 GS in all but 13 (99.3%) patients (median dose 50
GS.) and the minimum and maximum doses in the central plane of the breast
were within 95% and 110% of the dose to point A in 82% of patients. The dos
e to the tumor excision area (point B) was within the homogeneity criteria
in 97% of patients, and the boost doses were consistent with randomization
in 93% of cases. These data, based on one-third of the randomized patients
in trial 22881/10882 demonstrate a high level of homogeneity in radiation d
oses, despite a number of ambiguities in the protocol, which were efficient
ly clarified a few months after the beginning of the trial. This high level
of consistency is a remarkable achievement given the number of centers, th
e number of patients. and the number of countries involved in this trial.