Immunological parameters of apple allergy during hyposensitisation with birch pollen

During the therapy study 15 patients with birch pollen allergy and associat ed apple allergy were treated with two courses of pre-seasonal birch pollen immunotherapy. Changes in immunological parameters were investigated in an attempt to explain the beneficial effects on apple allergy seen in 9 patie nts (60%). We observed an improvement of pollen allergy in 13 patients (87% ). The results of immunoblot inhibition corroborated the importance from Be t v 1 and homological protein Mal d 1 in the apple. There are the basis for therapy effect to food allergy with birch pollen. The change of skin test reaction, birch pollen as apple-specific IgE-levels and the not significant ly change the specific antibody levels for Bet v 1 and Bet v 2 couldn't dem onstrated the clinical effect.