Radiotherapy to control CNS lymphomatoid granulomatosis: A case report andreview of the literature

Lymphomatoid granulomatosis (LG) is an uncommon but potentially fatal disea se, The disease primarily involves the lungs; however, skin, renal, and cen tral nervous system (CNS) are seen in varying proportions, Neurological inv olvement occurs in one third of the patients, and confers a worse prognosis . The use of radiotherapy to treat CNS involvement in LG has not been well studied. We report a case of a 33-year-old man with multiple CNS lesions tr eated successfully with radiotherapy and review 6 other cases in the litera ture using similar treatment. These cases support the use of radiotherapy f or CNS involvement in LG. (C) 1999 Wiley-Liss, Inc.