Soluble fas ligand in natural killer cell lymphoma

We measured serum soluble Fas ligand (sFasL) in a patient with natural kill er cell lymphoma, and investigated relationship between sFasL and liver dys function. An elevated level of sFasL was decreased after local radiation th erapy, and liver function improved. When lymphoma relapsed, liver dysfuncti on reappeared and the level of sFasL increased parallelly, Lymphoma cells e xpressed mRNA of Fast. This suggested that this liver dysfunction was induc ed by some remote effecters, and sFasL was one of candidates of these effec ters. (C) 1999 Wiley-Liss, Inc.