Carpal tunnel syndrome (CTS) is a clinical entity characterized by pain, pa
resthesias, and numbness in the distribution of the median nerve with weakn
ess and atrophy of the thenar muscles in advanced cases. It is universally
accepted that CTS is the clinical concomitant of compression of the median
nerve as it passes through the carpal canal. It is reported To be the most
common of the entrapment neuropathies. Increasing evidence suggests that oc
cupational factors, including forceful use of the hands, repetitive use of
the hands, and hand-ann vibration, are etiologic for CTS. When occurring as
a result of occupational exposures, the term "work-related carpal tunnel s
yndrome" is applied. Clinical approaches to the diagnosis and treatment of
work-related CTS are described in this paper. Particular attention is paid
to the clinical features and pathophysiology of CTS, the epidemiology of wo
rk-related CTS, ascertainment of work-relatedness in the clinical setting,
treatment including both work and non-work interventions, and control of oc
cupational ergonomic risk factors that may contribute to the illness. Am. J
. Ind. Med. 37:62-74, 2000. (C) 2000 Wiley-Liss, Inc.