Study of a molecular imprinting polymer coated BAW bio-mimic sensor and its application to the determination of caffeine in human serum and urine

A bio-mimic bulk acoustic wave (BAW) sensor was fabricated by coating the c affeine (CAF) template molecular imprinting polymer (MIP). This sensor exhi bited high selectivity and a sensitive mass response to CAF. The response r ange of the sensor was between 5.0 x 10(-9) and 1.0 x 10(-4) M with a detec tion limit of 5.0 x 10(-9) M at pH 8.0. Recoveries were 96.1-105.6%. Influe ncing factors were investigated in detail and optimized. When employed to d etect real samples, the proposed method proved to be a convenient method wi th the advantages of high sensitivity, good selectivity and ease of handlin g.