Adsorptive stripping voltammetric determination of albendazole at a hanging mercury drop electrode

Albendazole is determined by differential-pulse adsorptive cathodic strippi ng voltammetry at a hanging mercury drop electrode using the reduction peak of its copper(II) complex at -0.28V at an accumulation potential 0.0V vs. Ag/AgCl electrode. The optimum conditions of pH, accumulation potential and accumulation time were studied. The calibration graph for the determinatio n of albendazole was linear in the range 3.0X10(-8) - 9X10(-7)M with a rela tive standard deviation of 2.8%. The detection limit was 1.0X10(-8)M after 180s accumulation at 0.0V. The effect of common excipients and metal ions o n the peak height of albendazole was studied. The presence of Cu2+ ions for ms a stable complex with albendazole which is strongly adsorbed at the merc ury electrode surface. The method was applied to the determination of the d rug in commercially available dosage forms.