Xeroderma pigmentosum is a relatively rare systemic disease transmitted thr
ough an incomplete sex-linked recessive gene. It is characterized by malign
ant skin degeneration, One of the mast effective treatment choices for the
malignant changes is full-face resurfacing with skin grafts. Grafts harvest
ed from areas that have some freckles may show malignant degeneration by ul
traviolet exposure. The authors present a patient whose face was resurfaced
with a split-thickness skin graft and was admitted due to new tumor format
ion on her resurfaced face.