Characterization of a Mycobacterium smegmatis mutant lacking penicillin binding protein 1

Authors
Billman-Jacobe, H Haites, RE Coppel, RL
Citation
H. Billman-jacobe et al., Characterization of a Mycobacterium smegmatis mutant lacking penicillin binding protein 1, ANTIM AG CH, 43(12), 1999, pp. 3011-3013
Citations number
15
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
43
Issue
12
Year of publication
1999
Pages
3011 - 3013
Database
ISI
SICI code
0066-4804(199912)43:12<3011:COAMSM>2.0.ZU;2-P
Abstract
The ponA gene of Mycobacterium smegmatis encodes a 95-kDa penicillin bindin g protein, PBP1, that is similar to PBP1s of Mycobacterium tuberculosis and Mycobacterium leprae. Transposon disruption of ponA in M. smegmatis result ed in a PBP1-deficient mutant that was sensitive to beta-lactam antibiotics , was more permeable to glycine, and grew slowly in liquid culture.