Comparative bacteriostatic and bactericidal activities of cefodizime against Borrelia burgdorferi sensu lato

The MIC and MSC (minimum spirocheticidal concentration) and killing rate fo r Borrelia burgdorferi, the etiological agent of Lyme disease, were assesse d for cefodizime in comparison,with ceftriaxone, minocycline, azithromycin, roxithromycin, and ciprofloxacin. The range of cefodizime MICs was greater than those of azithromycin and roxithromycin but comparable to those of ce ftriaxone and minocycline. The MSCs were 1 to 2 dilutions higher than the M ICs of all of the tested compounds. The killing curves of cefodizime and ce ftriaxone showed parallel courses. In conclusion, cefodizime exerted an act ivity comparable to that of ceftriaxone against R. burgdorferi.