Beneficial effect of adjunctive azithromycin in treatment of mucoid Pseudomonas aeruginosa pneumonia in the murine model

Citation
Dp. Nicolau et al., Beneficial effect of adjunctive azithromycin in treatment of mucoid Pseudomonas aeruginosa pneumonia in the murine model, ANTIM AG CH, 43(12), 1999, pp. 3033-3035
Citations number
15
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
43
Issue
12
Year of publication
1999
Pages
3033 - 3035
Database
ISI
SICI code
0066-4804(199912)43:12<3033:BEOAAI>2.0.ZU;2-Q
Abstract
While a time-kill methodology noted no appreciable improvement in bacterici dal activity with the addition of azithromycin (AZM) to a ceftazidime (CAZ) regimen, data from the murine pneumonia model showed that the addition of AZM significantly improved survival compared to treatment with CAZ alone. T hese data suggest that AZM might be a useful adjunctive therapy in the mana gement of pneumonia resulting from mucoid isolates of Pseudomonas aeruginos a.