Beneficial effect of adjunctive azithromycin in treatment of mucoid Pseudomonas aeruginosa pneumonia in the murine model

While a time-kill methodology noted no appreciable improvement in bacterici dal activity with the addition of azithromycin (AZM) to a ceftazidime (CAZ) regimen, data from the murine pneumonia model showed that the addition of AZM significantly improved survival compared to treatment with CAZ alone. T hese data suggest that AZM might be a useful adjunctive therapy in the mana gement of pneumonia resulting from mucoid isolates of Pseudomonas aeruginos a.