Oral bioavailability and pharmacokinetics of trovafloxacin in patients with AIDS

Authors
Lacy, MK Nicolau, DP Nightingale, CH Geffken, A Teng, RL Vincent, J Quintiliani, R
Citation
Mk. Lacy et al., Oral bioavailability and pharmacokinetics of trovafloxacin in patients with AIDS, ANTIM AG CH, 43(12), 1999, pp. 3005-3007
Citations number
27
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
43
Issue
12
Year of publication
1999
Pages
3005 - 3007
Database
ISI
SICI code
0066-4804(199912)43:12<3005:OBAPOT>2.0.ZU;2-P
Abstract
Trovafloxacin pharmacokinetics were evaluated in 12 subjects with AIDS. By using a randomized design, single 200-mg doses of oral trovafloxacin and in travenous alatrofloxacin were administered. The mean absolute bioavailabili ty was 91%. The pharmacokinetics of trovafloxacin when administered orally as the active form or intravenously as the prodrug (alatrofloxacin) are not altered in subjects with AIDS compared to those in healthy adults.