Non-nucleoside reverse transcriptase inhibitors: the NNRTI boom

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are promising drug s for the treatment of HIV when used in combination with other anti-HIV dru gs such as nucleoside reverse transcriptase (RT) inhibitors and protease in hibitors. The first generation of NNRTIs have, however, suffered from the r apid development of resistance. This review discusses the properties of the FDA-approved NNRTI drugs and focuses on the recent efforts being made to p roduce second generation inhibitors that circumvent this resistance problem .