Under the basis of physiological data, a nonlinear and unsteady comprehensi
ve mathematical model of microcirculatory dynamics with distributed paramet
ers is developed. Hemodynmaics, interstitium dynamics, lymph dynamics, dyna
mics of protein transport, oxygen dynamics, dynamics of heat transfer, and
myogenic and metabolic regulation procedures are included. The interactions
between these factors were comprehensively exhibited. The influences of ar
teriolar vasomotion and nonlinear viscoelasticity of blood in arteriole are
considered. A simplified vessel network consisting of arteriole, open and
reserved capillaries, venule, initial lymphatics and arteriole-venule anast
omose is adopted as the geometrical model. This kind of comprehensive mathe
matical model is helpful in analyzing clinical data and developing a "numer
ical experiment method" in microcirculation research.