For a subset E of an integral domain D and an integer-valued polynomial f o
ver D, we investigate conditions under which the subsets E and f(E) of D de
termine the same integer-valued polynomials on D (this is the definition of
polynomial equivalence of E and f(E)). Our primary interest in this proble
m lies in the case where D is the ring of rational integers. Using work of
McQuillan, the case where E is finite is resolved completely in Section 3.
For E infinite we show in several cases that polynomial equivalence of E an
d f(E) implies that f is linear, but whether this is true in general for, s
ay, D = Z is an open question.