INHIBITION OF HUMAN-LEUKOCYTE PROTEINASE-3 BY A NOVEL RECOMBINANT SERINE PROTEINASE-INHIBITOR (LEX032)

Authors
GROUTAS WC RUAN SM KUANG RZ HOOK JB SANDS H
Citation
Wc. Groutas et al., INHIBITION OF HUMAN-LEUKOCYTE PROTEINASE-3 BY A NOVEL RECOMBINANT SERINE PROTEINASE-INHIBITOR (LEX032), Biochemical and biophysical research communications, 233(3), 1997, pp. 697-699
Citations number
38
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
233
Issue
3
Year of publication
1997
Pages
697 - 699
Database
ISI
SICI code
0006-291X(1997)233:3<697:IOHPBA>2.0.ZU;2-D
Abstract
The interaction of a bioengineered serpin (LEX032) with human leukocyt e proteinase 3 (PR 3) has been investigated. LEX032 was found to be a time-dependent inhibitor of PR 3, forming a highly-stable enzyme-inhib itor complex (K-i 12 nM). (C) 1997 Academic Press.