An alternative synthesis of N-acetyl-4-deoxyneuraminic acid

Authors
Ooi, HC Marcuccio, SM Jackson, WR
Citation
Hc. Ooi et al., An alternative synthesis of N-acetyl-4-deoxyneuraminic acid, AUST J CHEM, 52(10), 1999, pp. 937-940
Citations number
18
Categorie Soggetti
Chemistry
Journal title
AUSTRALIAN JOURNAL OF CHEMISTRY
ISSN journal
00049425 → ACNP
Volume
52
Issue
10
Year of publication
1999
Pages
937 - 940
Database
ISI
SICI code
0004-9425(1999)52:10<937:AASONA>2.0.ZU;2-2
Abstract
A synthesis of N-acetyl-4-deoxyneuraminic acid (11) from N-acetylneuraminic acid (1) via the corresponding unsaturated derivative (4) is described. Th is synthesis of the important N-acetylneuraminic acid aldolase (EC 4.1.3.3) inhibitor overcomes several difficulties associated with two previously pu blished syntheses.