The synthesis and X-ray crystal structure of phenylalanine-based N-benzyloxysuccinimides

Authors
Abell, AD Oldham, MD Moore, MM Robinson, WT
Citation
Ad. Abell et al., The synthesis and X-ray crystal structure of phenylalanine-based N-benzyloxysuccinimides, AUST J CHEM, 52(10), 1999, pp. 977-981
Citations number
20
Categorie Soggetti
Chemistry
Journal title
AUSTRALIAN JOURNAL OF CHEMISTRY
ISSN journal
00049425 → ACNP
Volume
52
Issue
10
Year of publication
1999
Pages
977 - 981
Database
ISI
SICI code
0004-9425(1999)52:10<977:TSAXCS>2.0.ZU;2-D
Abstract
X-Ray crystal structures of the N-benzyloxysuccinimide (8) and its unprotec ted amino analogue (6) have been determined to reveal the conformation of t he cycle and the constituent phenylalanine. An improved synthesis of C-benz yl-N-benzyloxysuccinimide (12), a simple, but nevertheless important member of this class of peptidomimetic, is also presented.