Solution conformation and dynamics of the trisaccharide fragments of the O-antigen of Vibrio cholerae O1, serotypes Inaba and Ogawa

Authors
Gonzalez, L Asensio, JL Ariosa-Alvarez, A Verez-Bencomo, V Jimenez-Barbero, J
Citation
L. Gonzalez et al., Solution conformation and dynamics of the trisaccharide fragments of the O-antigen of Vibrio cholerae O1, serotypes Inaba and Ogawa, CARBOHY RES, 321(1-2), 1999, pp. 88-95
Citations number
43
Categorie Soggetti
Agricultural Chemistry","Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
CARBOHYDRATE RESEARCH
ISSN journal
00086215 → ACNP
Volume
321
Issue
1-2
Year of publication
1999
Pages
88 - 95
Database
ISI
SICI code
0008-6215(19990915)321:1-2<88:SCADOT>2.0.ZU;2-V
Abstract
The conformational behavior of the trisaccharide fragments of the Ogawa and Inaba Vibrio cholera serotypes has been studied using NMR and molecular dy namics (MD). The obtained results indicate that there are no significant di fferences in the major conformation and in the extent of motion of the glyc osidic torsions of these molecules. The differences in biological activity are probably not due to conformational effects but to van der Waals and/or hydrogen bonding interactions between the antigens and the biological recep tor. (C) 1999 Elsevier Science Ltd. All rights reserved.