Isoform diversity and modulation of sodium channels by protein kinases

Although voltage-dependent sodium channels from the brain have been realize d as targets for regulatory protein phosphorylation since the first isolati on of sodium channels as proteins, the functional role of phosphoprotein fo rmation has been obscured until recently. The review summarizes progress on the modulation of voltage-dependent sodium channels by serine/threonine pr otein kinases, i.e. PKA and PKC. Divergent modulation is discussed in conte xt with divergent primary structure of the alpha-subunit. Copyright (C) 199 9 S. Karger AG, Basel.