Transthoracic needle biopsy (TNB) has become the diagnostic procedure of ch
oice in evaluation of focal chest lesions. Both advances in cross-sectional
image guidance and cytopathologic techniques allow TNB to accurately diagn
ose malignancy and characterize a spectrum of benign conditions. Image-guid
ed percutaneous drainage of intrathoracic collections has developed as an e
xtension of similar procedures in the abdomen and pelvis. The ability of CT
and ultrasound to accurately detect and characterize parenchymal and pleur
al collections, and advances in interventional techniques and catheter desi
gn, have made percutaneous catheter drainage the treatment of choice for a
variety of intrathoracic collections. This article provides an updated revi
ew of the spectrum of image-guided diagnostic and therapeutic procedures in
the thorax.