S. Ishiwata et al., MYOCARDIAL BLOOD-FLOW AND METABOLISM IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY - A STUDY WITH C-11 ACETATE AND POSITRON EMISSION TOMOGRAPHY, Japanese Circulation Journal, 61(3), 1997, pp. 201-210
The underlying pathophysiology of hypertrophic cardiomyopathy (HCM) is
still unclear. Positron emission tomography is a suitable and promisi
ng technique for the detection of possible metabolic consequences of t
he disease. To assess regional myocardial blood flow and metabolism, 1
9 asymptomatic or only mildly symptomatic patients with HCM and 10 nor
mal control subjects were studied using carbon-11 acetate and fluorine
-18-labelled deoxyglucose (FDG) as tracers of myocardial blood flow (A
o), oxygen consumption (k), and exogenous glucose utilization. In the
patients, regional Ao in the hypertrophied septum and apex (H) was sim
ilar to that in the nonhypertrophied free wall (N) (91.3 +/- 3.9% vs 9
2.9 +/- 3.1%; p = NS). However, the k values were significantly lower
in H than in N (0.044 +/- 0.012 vs 0.060 +/- 0.016/min, p < 0.0001). T
he k value in N and normal control subjects (0.062 +/- 0.013) was simi
lar. Postprandial FDG uptake was lower in H than in N (70 +/- 16 vs 91
+/- 7%; p < 0.0001) in 16 patients and,slightly higher in 3 patients.
Fasting FDG study showed increased FDG uptake in H in 3 out of 13 pat
ients, suggesting a disorder of the myocardial microvascular circulati
on. A relative decrease in hypertrophied septal and apical oxidative m
etabolism and glucose utilization without any corresponding perfusion
defect could reflect abnormal regional aerobic metabolism in the dispr
oportionately thickened myocardium in patients with HCM. This suggests
that a primary myocardial metabolic defect might be present in patien
ts with HCM.