New paradigms of signaling in the vasculature: ephrins and metalloproteases

As our understanding of the control of vasculogenesis and angiogenesis cont inues to grow, we will be confronted with an increasing number of interacti ng and intersecting receptor-mediated signaling pathways. if we are to be s uccessful in developing new and novel effective therapeutic reagents that c an function as stimulators or inhibitors of these critically important proc esses, we will have to develop a sophisticated, full understanding of the c omplex interactions associated with ephrin-based and metalloprotease-based signaling pathways.