Progression into and out of mitosis

Progression through mitosis is controlled by cyclin-dependent kinases, whic h drive cells into metaphase, and by the anaphase-promoting complex/cycloso me, a ubiquitin ligase that triggers sister chromatid separation and exit f rom mitosis. Recent work has shown how the mutual regulation between cyclin -dependent kinases and the anaphase-promoting complex/cyclosome ensures tha t cell-cycle events occur in the right order. The analysis of complexes req uired for sister chromatid cohesion and chromosome condensation has reveale d how cyclin-dependent kinases and the anaphase-promoting complex/cyclosome control the behaviour of chromosomes.