Citation
K. Bloom et Dl. Beach, mRNA localization: motile RNA, asymmetric anchors, CURR OPIN M, 2(6), 1999, pp. 604-609
Citations number
46
Categorie Soggetti
Biotecnology & Applied Microbiology",Microbiology
Journal title
CURRENT OPINION IN MICROBIOLOGY
ISSN journal
13695274
→ ACNP
Volume
2
Issue
6
Year of publication
1999
Pages
604 - 609
Database
ISI
SICI code
1369-5274(199912)2:6<604:MLMRAA>2.0.ZU;2-1
Abstract
Techniques to label mRNA with green fluorescent protein (GFP) have provided
the first real-time images of RNA motility in live yeast cells. Genetic sc
reens for factors responsible for mRNA asymmetry (e.g. SHE genes) in yeast
identified type V myosin among other proteins. Analysis of mRNA movement in
various she mutants revealed the role of motor proteins in long-range tran
sport, factors for particle formation, and cortical anchors for docking the
mRNA.