Use of lispro insulin and quality of life in adolescents on intensive therapy

PURPOSE This study examined the metabolic and quality-of-life effects of using lisp ro insulin in teenagers. METHODS Teenagers on multiple daily injections who had not reached metabolic treatm ent goals were offered the opportunity to use lispro insulin as part of a l arger ongoing study of intensive management in youth. Of the 51 who were el igible, 35 used lispro and were followed for 12 months; the remaining 16 ha d reached treatment goals, were not offered lispro, and comprised the contr ol group. RESULTS After 12 months, the teens who received lispro insulin achieved equivalent levels of metabolic control to those achieved by teens in the control group , without differences ill total daily dose, insulin regimen or adverse even ts. Those who received lispro found coping with diabetes less difficult tha n those who continued on regular insulin, and they reported less negative i mpact of diabetes on quality of life and fewer worries about diabetes. Both groups were equally satisfied with their diabetes treatment. CONCLUSIONS Lispro insulin is a safe alternative for youth on intensive regimens, may a ssist youth in coping With diabetes, and may improve their quality of life.