Effective management of natural resources must be grounded in a solid scien
tific understanding of the ecosystem and its responses to natural and human
-induced stress. Such an understanding does not arise easily from observati
onal data and models that are not substantiated by experimental data. Cause
-and-effect relationships are more easily documented when observations and/
or models are supplemented by hypothesis-driven experimental research. In t
his paper we present three examples from south Florida where hypothesis-dri
ven experimental research has been combined with observational data collect
ion to address specific resource management questions. These include resear
ch to determine: (I)the cause of cattail expansion in the Everglades; (2) a
threshold phosphorus concentration for the Everglades; and (3) optimal sal
inity criteria for Florida estuaries. In each case, the results have led to
a better understanding of ecosystem function and more sound guidance for r
esource managers than was possible without the hypothesis-drive experimenta
l research. Resource managers need to recognize the merits of this holistic
approach to environmental science and management if we are to have success
in reversing detrimental human impacts on natural ecosystems.