Genetic linkage analysis with dyslexia: Evidence for linkage of spelling disability to chromosome 15

Citation
Mm. Nothen et al., Genetic linkage analysis with dyslexia: Evidence for linkage of spelling disability to chromosome 15, EUR CHILD A, 8, 1999, pp. 56-59
Citations number
16
Categorie Soggetti
Psychiatry
Journal title
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
ISSN journal
10188827 → ACNP
Volume
8
Year of publication
1999
Supplement
3
Pages
56 - 59
Database
ISI
SICI code
1018-8827(1999)8:<56:GLAWDE>2.0.ZU;2-C
Abstract
Dyslexia (reading and spelling disability) is one of the most frequently di agnosed disorders in childhood. Twin studies of dyslexia have indicated tha t deficits in spelling are substantially heritable and that the heritabilit y of spelling deficits is higher than the heritability of reading deficits. We conducted a linkage study for spelling disability in seven multiplex fa milies from Germany. Following previously reported linkage findings of comp onents of dyslexia to chromosome 6p21-p22 and 15q21, we genotyped 26 micros atellite markers covering all of chromosome 6, and 13 microsatellite marker s covering all of chromosome 15. While the chromosome 6 data were negative, results from chromosome 15 markers supported a locus on 15q21. The highest two-point LOD score was 1.26 with marker D15S143 at theta = 0. A multipoin t LOD score of 1.78 (p = 0.0042) was achieved with a maximum at D15S132. Th us, our results provide independent support for a dyslexia gene on the long arm of chromosome 15.