Background: Reactive oxygen species have been considered to play a role in
several clinical complications in pre-term infants. The aim of this study w
as to determine the pharmacokinetics of intravenous N-acetylcysteine in pre
-term neonates. This information is needed to evaluate the use of N-acetylc
ysteine as an antioxidant in this patient group.
Methods: N-acetylcysteine was infused intravenously in ten patients (gestat
ional age 24.9-31.0 weeks, weight 500-1384 g) for 24 h (3.4-4.6 mg/kg/h), s
tarting 2.0-11.2 h from birth (study I) and in six patients (gestational ag
e 25.9-29.7 weeks, weight 520-1335 g) for 6 days (0.3-1.3 mg/kg/h), startin
g at the age of 24 h (study II). Arterial plasma N-acetylcysteine and cyst(
e)ine concentrations were determined from timed samples taken during (study
I and II) and after (study I) the N-acetylcysteine infusion.
Results: In study I, the mean elimination half-life of N-acetylcysteine was
11 h (range 7.8-15.2 h). The mean plasma clearance of N-acetylcysteine was
37 ml/kg/h (range 13-62 ml/kg/h) and the mean volume of distribution was 5
73 ml/kg (range 167-1010 ml/kg). The plasma clearance and volume of distrib
ution correlated with weight (r = 0.81, P < 0.01, and r = 0.78, P < 0.01, r
espectively) and with gestational age (r = 0.71, P < 0.05, and r = 0.64, P
< 0.05, respectively). In study II, the steady-state concentration of N-ace
tylcysteine was reached in 2-3 days in five of six patients during a consta
nt infusion.
Conclusions: The pharmacokinetics of N-acetylcysteine in pre-term infants d
epend markedly on weight and gestational age. The elimination of N-acetylcy
steine is much slower in pre-term new-borns than in adults.