Pl. Cherchi et al., Immunohistochemical expression of BerEP4, a new epithelial antigen, in endometrial carcinoma: correlation with clinical parameters, EUR J GYN O, 20(5-6), 1999, pp. 393-395
Objective: To assess the immunochemical expression of BerEP4, a new epithel
ial antigen in endometrial carcinoma.
Methods: We studied 45 cases of endometrial carcinoma in which the BerEP4,
CEA and TAG-72 antigens were searched by an immunohistochemical method. We
evaluated the correlations among the immunohistochemical positivity and the
grading, histotype, stage and receptorial status of the neoplasia.
Results: CEA was positive in 29 out of 45 cases (64.4%), TAG-72 in 17 out o
f 45 cases (37.7%) and BerEP4 in 31 out of 45 cases (68.9%). Both TAG-72 an
d CEA were inversely related to the grading while, with regard to the histo
type, CEA resulted as highly positive in the 5 cases of adenoacanthoma.
Conclusion: BerEP4 did not show any correlation with grading, histotype, st
age of disease or receptorial status of the carcinoma.