Immunohistochemical expression of BerEP4, a new epithelial antigen, in endometrial carcinoma: correlation with clinical parameters

Citation
Pl. Cherchi et al., Immunohistochemical expression of BerEP4, a new epithelial antigen, in endometrial carcinoma: correlation with clinical parameters, EUR J GYN O, 20(5-6), 1999, pp. 393-395
Citations number
5
Categorie Soggetti
Reproductive Medicine
Journal title
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
ISSN journal
03922936 → ACNP
Volume
20
Issue
5-6
Year of publication
1999
Pages
393 - 395
Database
ISI
SICI code
0392-2936(1999)20:5-6<393:IEOBAN>2.0.ZU;2-0
Abstract
Objective: To assess the immunochemical expression of BerEP4, a new epithel ial antigen in endometrial carcinoma. Methods: We studied 45 cases of endometrial carcinoma in which the BerEP4, CEA and TAG-72 antigens were searched by an immunohistochemical method. We evaluated the correlations among the immunohistochemical positivity and the grading, histotype, stage and receptorial status of the neoplasia. Results: CEA was positive in 29 out of 45 cases (64.4%), TAG-72 in 17 out o f 45 cases (37.7%) and BerEP4 in 31 out of 45 cases (68.9%). Both TAG-72 an d CEA were inversely related to the grading while, with regard to the histo type, CEA resulted as highly positive in the 5 cases of adenoacanthoma. Conclusion: BerEP4 did not show any correlation with grading, histotype, st age of disease or receptorial status of the carcinoma.