Insight into regulatory factor targeting to transcriptionally active subnuclear sites

Mechanisms that coordinate the spatial organization of genes and regulatory proteins within the three-dimensional context of nuclear architecture cont ribute to the sorting of regulatory information as well as the assembly and activity of sites within the nucleus that support gene expression. In this article we will present an overview of experimental approaches that provid e insight into the trafficking of the hematopoietic and bone-specific AML/C BF family of regulatory factors to transcriptionally active subnuclear site s. (C) 1999 Academic Press.