Jv. Mysore et al., Treatment of Helicobacter pylori infection in rhesus monkeys using a novelantiadhesion compound, GASTROENTY, 117(6), 1999, pp. 1316-1325
Background ge Aims: Helicobacter pylori can be eradicated by administration
of antimicrobials, but resistant strains have emerged, and there is a need
for novel therapeutic approaches against this infection, This study aimed
to determine the safety and efficacy of 3'-sialyllactose sodium salt (3'SL)
, an oligosaccharide that occurs naturally in human and bovine milk and tha
t can inhibit the adhesion of H. pylori to human epithelial cells in vitro,
Methods: Twelve H. pylori-positive rhesus monkeys were given 3'SL, either
alone (regimens 1 and 2; n = 6) or in combination with omeprazole (regimen
3; n = 4), or bismuth subsalicylate (regimen 4; n = 6), Videogastroscopies
were performed before, during, and after treatment, and gastric biopsy spec
imens were obtained for quantitative cultures and histology, The H. pylori
strains colonizing the animals were genotyped, Results: After regimen 1 or
2, 2 of 6 animals were cured permanently, and a third animal was transientl
y cleared. The 3 other animals remained persistently colonized and did not
respond to regimen 3, Regimen 4 resulted in transient decreases in colony c
ounts in 3 of 6 other animals. Gastritis was suppressed only in the 2 anima
ls who became persistently H. pylori negative. There was no apparent relati
on between 3'SL efficacy and any of the H. pylori tested genotypes, No side
effects were observed in any of the animals receiving 3'SL, Conclusions: A
ntiadhesive therapy is safe; it can cure or decrease H, pylori colonization
in some rhesus monkeys, but the addition of a proton pump inhibitor or bis
muth subsalicylate does not increase cure rate.