The use of yeast artificial chromosomes in transgenic animals: expression studies of the tyrosinase gene in transgenic mice

Authors
Giraldo, P Gimenez, E Montoliu, L
Citation
P. Giraldo et al., The use of yeast artificial chromosomes in transgenic animals: expression studies of the tyrosinase gene in transgenic mice, GENET A-BIO, 15(3-5), 1999, pp. 175-178
Citations number
28
Categorie Soggetti
Molecular Biology & Genetics
Journal title
GENETIC ANALYSIS-BIOMOLECULAR ENGINEERING
ISSN journal
10503862 → ACNP
Volume
15
Issue
3-5
Year of publication
1999
Pages
175 - 178
Database
ISI
SICI code
1050-3862(199911)15:3-5<175:TUOYAC>2.0.ZU;2-U
Abstract
Variegation and inherited somatic mosaicism has been observed in transgenic mice carrying yeast artificial chromosomes (YACs) in which a DNAse I hyper sensitive site (HS) located - 12 kb upstream of the mouse tyrosinase gene h ad been deleted. At present, we are generating new transgenic animals with minor deletions of the HS. (C) 1999 Elsevier Science B.V. All rights reserv ed.