P. Giraldo et al., The use of yeast artificial chromosomes in transgenic animals: expression studies of the tyrosinase gene in transgenic mice, GENET A-BIO, 15(3-5), 1999, pp. 175-178
Variegation and inherited somatic mosaicism has been observed in transgenic
mice carrying yeast artificial chromosomes (YACs) in which a DNAse I hyper
sensitive site (HS) located - 12 kb upstream of the mouse tyrosinase gene h
ad been deleted. At present, we are generating new transgenic animals with
minor deletions of the HS. (C) 1999 Elsevier Science B.V. All rights reserv
ed.