Signaling through gp130: Toward a general scenario of cytokine action

Authors
Fukada, T Yoshida, Y Nishida, K Ohtani, T Shirogane, T Hibi, M Hirano, T
Citation
T. Fukada et al., Signaling through gp130: Toward a general scenario of cytokine action, GROW FACTOR, 17(2), 1999, pp. 81-91
Citations number
84
Categorie Soggetti
Cell & Developmental Biology
Journal title
GROWTH FACTORS
ISSN journal
08977194 → ACNP
Volume
17
Issue
2
Year of publication
1999
Pages
81 - 91
Database
ISI
SICI code
0897-7194(1999)17:2<81:STGTAG>2.0.ZU;2-K
Abstract
Cytokines play roles in a wide range of responses such as immune response, hematopoiesis and inflammation. A large volume of studies revealed that cyt okines show functional pleiotropy and redundancy. Gp130 is a receptor subun it shared by the interleukin-6 family of cytokines, We describe and discuss signaling through gp130 in relation to a general scenario for cytokine sig naling regulating cell growth, differentiation and survival.