Model-free analysis and permutation tests for allelic associations

Authors
Zhao, JH Curtis, D Sham, PC
Citation
Jh. Zhao et al., Model-free analysis and permutation tests for allelic associations, HUMAN HERED, 50(2), 2000, pp. 133-139
Citations number
19
Categorie Soggetti
Molecular Biology & Genetics
Journal title
HUMAN HEREDITY
ISSN journal
00015652 → ACNP
Volume
50
Issue
2
Year of publication
2000
Pages
133 - 139
Database
ISI
SICI code
0001-5652(200003/04)50:2<133:MAAPTF>2.0.ZU;2-U
Abstract
In this short report, we address some practical problems in performing like lihood-based allelic association analysis of case-control data. Model-free statistics are proposed and their properties assessed by simulation, and pr ocedures based on permutation tests a re described for marker-marker as wel l as marker-disease associations. A memory-efficient algorithm is developed which enables several highly polymorphic markers to be analysed. Copyright (C) 1999 S. Karger AG, Basel.