Categorical classifications of mental disorders do not take into account th
e subthreshold, atypical and often enduring symptoms that accompany the cor
e manifestations of full-blown mental disorders. However, this often neglec
ted spectrum of symptoms may be as distressing and debilitating as the full
-blown disorder and may have unrecognized importance in treatment selection
and response. To this end, a spectrum approach to mental disorders, such a
s bipolar, obsessive-compulsive, eating, and panic disorder has been develo
ped, which has been extensively used and proven effective in clinical pract
ice. The need for a systematic identification and assessment of a broad arr
ay of symptoms and behavioural features led, as a first step, to the concep
tualization of the panic-agoraphobic spectrum model and to the development
of a structured interview (SCI-PAS). This model has been constructed by ide
ntifying different psychopathological and clinical domains incorporating an
d extending Panic Disorder as described in DSM-IV. The rationale, clinical
usefulness, and heuristic significance of the panic-agoraphobic spectrum mo
del will be discussed. Copyright (C) 1999 John Wiley & Sons, Ltd.