Immune evasion of tumor cells using membrane-bound complement regulatory proteins

Authors
Gorter, A Meri, S
Citation
A. Gorter et S. Meri, Immune evasion of tumor cells using membrane-bound complement regulatory proteins, IMMUNOL TOD, 20(12), 1999, pp. 576-582
Citations number
78
Categorie Soggetti
Immunology
Journal title
IMMUNOLOGY TODAY
ISSN journal
01675699 → ACNP
Volume
20
Issue
12
Year of publication
1999
Pages
576 - 582
Database
ISI
SICI code
0167-5699(199912)20:12<576:IEOTCU>2.0.ZU;2-M
Abstract
Membrane-bound complement regulatory proteins (mCRPs) play an important rol e in the protection of cells from complement-mediated injury. It is now app arent that malignant tumor cells also express these proteins to escape comp lement attack. Here, Arko Gorter and Seppo Meri discuss the implications of complement resistance for the immunotherapeutic treatment of solid tumors with monoclonal antibodies.