NMR studies of the R2 repeat and related peptide fragments of the DNA binding domain of c-Myb. New light on the structure and folding of R2

The solution structure of the R2 repeat of the DNA binding domain of the pr otooncogene c-Myb contains a N-terminal structural motif comprising two ant iparallel helices. The motif is stabilized by interactions involving conser ved residues. The recognition region in C-terminal position is flexible. Th is structure differs from that of R2 of another c-Myb protein.