Steroidal aphidicolin analogues derived from pregnenolone

Authors
Hanson, JR Yildirim, K
Citation
Jr. Hanson et K. Yildirim, Steroidal aphidicolin analogues derived from pregnenolone, J CHEM R-S, (12), 1999, pp. 698-699A
Citations number
17
Categorie Soggetti
Chemistry
Journal title
JOURNAL OF CHEMICAL RESEARCH-S
ISSN journal
03082342 → ACNP
Issue
12
Year of publication
1999
Pages
698 - 699A
Database
ISI
SICI code
0308-2342(199912):12<698:SAADFP>2.0.ZU;2-X
Abstract
The conversion of pregnenolone into the 3 beta,5 alpha-, 3 alpha,5 alpha-, 4 beta,5 alpha-, 3 alpha,4 alpha-, 3 alpha,4 beta- and 3 alpha,4 alpha-dihy droxy derivatives of 17 beta-hydroxymethyl-5 alpha-androstane as steroidal analogues of the diterpenoid DNA polymerase alpha inhibitor, aphidicolin, i s described.