Cm. Liao et al., Tissue distribution and kinetics of dietary and waterborne zinc in abalone(Haliotis diversicolor supertexta), J ENVIR S A, 34(10), 1999, pp. 1945-1966
Citations number
18
Categorie Soggetti
Environment/Ecology
Journal title
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING
Uptake and depuration of dietary and waterborne zinc (Zn(II)) were examined
in aquaculture abalone Haliotis diversicolor supertexta and red alga Graci
laria tenuistipitata var, liui using a simple first-order one-compartment b
ioaccumulation model. A six-compartment physiologically based pharmacokinet
ic model of the disposition of Zn(II) in abalone key organs was developed t
o predict tissue distributions. A mean residence time concept was also used
to measure the biological persistence for disposition of Zn(II) in each ta
rget tissue. The one-compartment kinetic model was successfully fitted to d
etermine uptake and depuration rates based on a 14-d exposure experiment. R
esults indicated that estimating uptake and depuration rates from depuratio
n and short-term uptake experiments was a reliable method of predicting ste
ady-state bioconcentration and biomagnification factors. Simulations using
the six-compartment pharmacokinetic model for both water and food exposure
routes indicated that the whole body Zn(II) concentration would reach equil
ibrium in about 120 d. Zn(II) however did not attain a steady-state in the
soft tissue and the shell. It is concluded that a pharmacokinetic model is
necessary for assessment of Zn(II) risk to abalone key tissues based on the
Zn(II)-dynamics in target compartments.