Comparison of functional capacity in patients with end-stage heart failurefollowing implantation of a left ventricular assist device versus heart transplantation: Results of the experience with left ventricular assist device with exercise trial
Be. Jaski et al., Comparison of functional capacity in patients with end-stage heart failurefollowing implantation of a left ventricular assist device versus heart transplantation: Results of the experience with left ventricular assist device with exercise trial, J HEART LUN, 18(11), 1999, pp. 1031-1040
Background: Use of a permanent left ventricular assist device (LVAD) has be
en proposed as an alternate treatment of patients with end-stage heart fail
ure. The purpose of this study was to compare the functional capacity of pa
tients following implantation of a LVAD vs heart transplant (HTx).
Methods: Eighteen patients from 6 centers who received an intracorporeal LV
AD as a bridge to HTx underwent treadmill testing 1 to 3 months post-LVAD a
nd again post-HTx. Baseline and peak measurements, including oxygen consump
tion, blood pressures, and respiratory rate were made during each treadmill
test.
Results: Peak oxygen consumption was 14.5 +/- 3.9 ml/kg/minute post-LVAD an
d 175 +/- 5.0 ml/kg/minute post-HTx (p < .005). The percentage of the predi
cted peak oxygen consumption based on gender, weight, and age was 39.5% +/-
5.5% post-LVAD and 47.7% +/- 10.9% post-HTx (p < .005). Exercise duration
was lower post-LVAD than post-HTx (10.3 +/- 4.2 minute vs 12.5 +/- 5.4 minu
te, p < .05). After LVAD implantation, peak total oxygen consumption correl
ated with peak LVAD rate and output. Eight patients reached an LVAD rate of
120 beats per minute (bpm) before the conclusion of exercise, the maximum
rate for the outpatient electric device. The peak respiratory exchange rati
o post-LVAD was 1.15 +/- 0.22 and post-HTx was 1.15 +/- 0.18, consistent wi
th a good effort in both groups.
Conclusions: Patients demonstrated a lower functional capacity post-LVAD th
an post-HTx. For some patients functional capacity post-LVAD may be improve
d by a higher maximum LVAD rate and output.