Epidemiology of biliary atresia in France: a national study 1986-96

Citation
C. Chardot et al., Epidemiology of biliary atresia in France: a national study 1986-96, J HEPATOL, 31(6), 1999, pp. 1006-1013
Citations number
49
Categorie Soggetti
Gastroenerology and Hepatology","da verificare
Journal title
JOURNAL OF HEPATOLOGY
ISSN journal
01688278 → ACNP
Volume
31
Issue
6
Year of publication
1999
Pages
1006 - 1013
Database
ISI
SICI code
0168-8278(199912)31:6<1006:EOBAIF>2.0.ZU;2-B
Abstract
Background/Aims: The reported incidence of biliary atresia varies from 5 to 32/100 000 live births. The existence of seasonality and/or clustering is controversial. Based on a large population analysis, we examined the incide nce of biliary atresia in France, and the space-time distribution of cases. Methods: All patients with biliary atresia living in France and born in the years 1986-96 were recorded. Geographic distribution, seasonality, time cl ustering and space-time clustering were analysed. Statistical analysis used the Chi square test, the Spearman nonparametric correlation test, the Walt er and Elwood test for seasonality of events and Knox analysis for time and space-time clustering. Results: We identified 461 patients: 421 born in metropolitan France (incid ence 5.12 [4.63-5.61]/100 000 live births), and 40 born in overseas territo ries. No significant regional variation in incidence was found in metropoli tan France, while the incidence was higher in French Polynesia (incidence 2 9.4 [15.4-43.3]/100 000 live births) (p<0.001). Seasonality, time-clusterin g and time-space clustering could not be demonstrated. Conclusions: 1) The incidence of BA was 5.7-fold higher in Polynesia than i n metropolitan France. 2) Neither seasonal variation in incidence nor clust ering was identified.